Beilstein J. Nanotechnol.2015,6, 1457–1466, doi:10.3762/bjnano.6.151
, Austria 10.3762/bjnano.6.151 Abstract The small intestine is a complex system that carries out various functions. The main function of enterocytes is absorption of nutrients, whereas membranous cells (Mcells) are responsible for delivering antigens/foreign substances to the mucosal lymphoid tissues
topographies of Caco-2 cells and Mcells. Furthermore, cell elasticity (i.e., the mechanical response of a cell on a tip indentation), was elucidated by force curve measurements. Besides elasticity, adhesion was evaluated by recording the attraction and repulsion forces between the tip and the cell surface
cytoskeleton/microvilli arrangements and F-actin organization. Caco-2 cells displayed densely packed F-actin bundles covering the entire cell surface, indicating the formation of a well-differentiated brush border. In contrast, in Mcells actins were arranged as short and/or truncated thin villi, only
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Figure 1:
SEM analyses of the Caco-2 monolayer (A, B) and the Caco-2/M cell co-culture (C, D). The most promi...
Beilstein J. Nanotechnol.2014,5, 2092–2101, doi:10.3762/bjnano.5.218
, specialized cell types such as Mcells or dendritic cells exist at certain mucosal sites [24][25]. These gateways, intended for the delivery of antigenic matter to the mucosal immune system, may be hijacked by anthropogenic NPs leading to an accumulation of NPs in gut-associated lympoid tissue as indicated by
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Figure 1:
Overview of the intestinal features relevant to the experimental setup. A: The rat intestinal expla...